Products: ImmunoINTEL

List of standard human-specific antibody panels**

  • Lymphocyte-Focused Antibody Panels
    • Lymphocyte panel (T Cells, B Cells, NK Cells)
    • Treg panel (T Cells and Treg)
  • Myeloid Cell-Focused Antibody Panels
    • Dendritic cell panel (pDC and mDC)
    • MDSC panel (Myeloid Derived Suppressor Cells)
    • Monocyte/Macrophage panel (M1 Mɸ, M2 Mɸ, and Monocytes)
  • General TME Antibody Panel
    • TME panel (Leukocytes, Epithelial Cells, Endothelial Cells, and Mesenchymal Cells)

Functional assays and readouts for identified cell populations (can be performed in dissociated tumors, matched adjacent “normal” tissue, and/or matched peripheral blood or bone marrow)

  • IMR and IMR-L qualitative identification and quantification of expression on multiple cell types
  • Intracellular signaling pathways (phospho-epitope readouts showing pathway activation or repression, +/- therapeutic)
  • Cytokine profiling (intra-cellular and extra-cellular cytokine quantification, Th1 versus Th2 balance, inflammatory cytokine signature, etc)
  • Effector molecule quantification (Granzyme B in CD8 T cells)
  • Th1, Th2, Th17 long term induction assays (1-2 weeks)
  • Receptor occupancy assays to determine drug-on/drug-off
  • PK/PD assays to suite client needs

**“Backbone” ImmunoINTEL antibody panels have been optimized using clinically relevant tissue types: (a) Peripheral blood, (b) Isolated PBMCs, and (c) Dissociated tumors